Nurix to provide a clinical update from the ongoing Phase 1 trial of NX-2127 in patients with hematologic malignancies
SAN FRANCISCO, Nov. 03, 2022 (GLOBE NEWSWIRE) -- Nurix Therapeutics, Inc. (Nasdaq: NRIX), a clinical-stage biopharmaceutical company developing targeted protein modulation drugs designed to treat patients with hematologic malignancies and solid tumors, today announced that its clinical-stage BTK degrader programs will be featured in two oral presentations and one poster presentation at the 64th American Society of Hematology Annual Meeting and Exposition being held December 10-13, 2022 in New Orleans, LA. The oral presentation by Dr. Anthony Mato of Memorial Sloan Kettering Cancer Center will include a clinical update on chronic lymphocytic leukemia patients from Nurix’s ongoing Phase 1 trial of NX-2127.
Oral Presentation Details:
Title: NX-2127-001, a First-in-Human Trial of NX-2127, a Bruton’s Tyrosine Kinase-Targeted Protein Degrader, in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia and B-Cell Malignancies
Speaker: Anthony Mato, M.D., MSCE, Director of the Chronic Lymphocytic Leukemia (CLL) Program at Memorial Sloan Kettering Cancer Center
Presentation Time: 5:30 PM CT
Session Name: 642. Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Drugs in Development and COVID-19
Session Date and Time: Monday, December 12, 2022, 4:30 PM - 6:00 PM CT
Location: Ernest N. Morial Convention Center, 243-245
Publication Number: 965
Title: Kinase Dead BTK Mutations Confer Resistance to Covalent and Noncovalent BTK Inhibitors but Are Susceptible to Clinical Stage BTK Degraders
Speaker: Omar Abdel-Wahab, M.D., Director of the Center for Hematologic Malignancies at Memorial Sloan Kettering Cancer Center
Presentation Time: 11:45 am CT
Session Name: 641. Chronic Lymphocytic Leukemias: Basic and Translational: Novel Therapies and Biomarkers
Session Date and Time: Monday, December 12, 2022, 10:30 AM - 12:00 PM CT
Location: Ernest N. Morial Convention Center, La Nouvelle Orleans Ballroom AB
Publication Number: 750
Poster Presentation Details:
Title: Bruton’s Tyrosine Kinase (BTK) degrader NX-2127 exhibits lethal activity and synergy with venetoclax and BET protein inhibitor against MCL cells sensitive or resistant to covalent BTK inhibitors
Authors: Warren Fiskus, Kaberi Das, Christopher Mill, Christine Birdwell, John Davis, Noor Alhamadani, Kevin Philip, May Tan, Robert Brown, Michael Green, and Kapil N. Bhalla
Session Name: 605. Molecular Pharmacology and Drug Resistance
Lymphoid Neoplasms: Poster II
Session Date and Time: Sunday, December 11, 2022, 6:00 PM - 8:00 PM CT
Location: Ernest N. Morial Convention Center, Hall D
Publication Number: 2663
NX-2127 is a novel bifunctional molecule that degrades Bruton’s tyrosine kinase (BTK) and cereblon neosubstrates Ikaros (IKZF1) and Aiolos (IKZF3). NX-2127 is currently being evaluated in a Phase 1 clinical trial in patients with relapsed or refractory B cell malignancies. Additional information on the ongoing clinical trial can be accessed at www.clinicaltrials.gov (NCT04830137).
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development and commercialization of small molecule and cell therapies based on the modulation of cellular protein levels as a novel treatment approach for cancer and other challenging diseases. Leveraging extensive expertise in E3 ligases together with proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels. Nurix’s wholly owned pipeline includes targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California. For additional information visit http://www.nurixtx.com.
Forward Looking Statement
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Elizabeth Wolffe, Ph.D.
Wheelhouse Life Science Advisors