<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2023 Workiva-->
<!--r:d8ac7d05-e19f-4024-b50f-58311280dc91,g:27390ebb-e85a-4d17-8805-9c394327b637-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.nurixtx.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="nrix-20230531.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:calculationLink xlink:role="http://www.nurixtx.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_cd8091be-dd8a-4bbb-9feb-dd3332b46152" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_c23734fe-be56-45fd-bf83-2b680771682b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_cd8091be-dd8a-4bbb-9feb-dd3332b46152" xlink:to="loc_us-gaap_LiabilitiesCurrent_c23734fe-be56-45fd-bf83-2b680771682b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_c266f4fc-f450-4f1d-b24b-56e00472f153" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_cd8091be-dd8a-4bbb-9feb-dd3332b46152" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_c266f4fc-f450-4f1d-b24b-56e00472f153" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_43b5646e-206d-4f58-93ce-1082747fa77f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_cd8091be-dd8a-4bbb-9feb-dd3332b46152" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityNoncurrent_43b5646e-206d-4f58-93ce-1082747fa77f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_95222737-b3a2-4f6b-a41c-56ff3711b725" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_de938a90-81e4-4809-869c-f53b84ac529d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_95222737-b3a2-4f6b-a41c-56ff3711b725" xlink:to="loc_us-gaap_Liabilities_de938a90-81e4-4809-869c-f53b84ac529d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_d4dd05e2-bcd2-4f46-a3b2-b2670639fbaf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_95222737-b3a2-4f6b-a41c-56ff3711b725" xlink:to="loc_us-gaap_CommitmentsAndContingencies_d4dd05e2-bcd2-4f46-a3b2-b2670639fbaf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_c159e763-685a-4ae2-97c5-ca9ff29aa1a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_95222737-b3a2-4f6b-a41c-56ff3711b725" xlink:to="loc_us-gaap_StockholdersEquity_c159e763-685a-4ae2-97c5-ca9ff29aa1a8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_3676db59-b166-4802-8244-fc36751f350b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_e8e887e2-0670-46af-8c9b-5b5a3471f6fe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_3676db59-b166-4802-8244-fc36751f350b" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_e8e887e2-0670-46af-8c9b-5b5a3471f6fe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesCurrent_533dec7a-012b-4e96-92f3-9026f394a400" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MarketableSecuritiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_3676db59-b166-4802-8244-fc36751f350b" xlink:to="loc_us-gaap_MarketableSecuritiesCurrent_533dec7a-012b-4e96-92f3-9026f394a400" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_79493f7b-80d7-4b83-893b-a3430f0dd4ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_3676db59-b166-4802-8244-fc36751f350b" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_79493f7b-80d7-4b83-893b-a3430f0dd4ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_f259a7fd-9870-4e9c-a35d-3aec842562ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_2372a9d7-1c0b-4a63-93fa-1bb4a9ad85db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_f259a7fd-9870-4e9c-a35d-3aec842562ef" xlink:to="loc_us-gaap_AssetsCurrent_2372a9d7-1c0b-4a63-93fa-1bb4a9ad85db" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MarketableSecuritiesNoncurrent_b489593f-c417-4852-82ff-43e3abcddad2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MarketableSecuritiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_f259a7fd-9870-4e9c-a35d-3aec842562ef" xlink:to="loc_us-gaap_MarketableSecuritiesNoncurrent_b489593f-c417-4852-82ff-43e3abcddad2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_c9a8e24b-81d5-4401-97f9-4aef9a8e1ffc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_f259a7fd-9870-4e9c-a35d-3aec842562ef" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_c9a8e24b-81d5-4401-97f9-4aef9a8e1ffc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_50900c2d-68c6-4346-b24a-b7a73578259c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_f259a7fd-9870-4e9c-a35d-3aec842562ef" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_50900c2d-68c6-4346-b24a-b7a73578259c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_c44ece98-6c17-4f43-9504-cc72a8983c10" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_f259a7fd-9870-4e9c-a35d-3aec842562ef" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_c44ece98-6c17-4f43-9504-cc72a8983c10" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_d156bacd-d27c-485e-b3cf-97c22f45f35d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_f259a7fd-9870-4e9c-a35d-3aec842562ef" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_d156bacd-d27c-485e-b3cf-97c22f45f35d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_078823e7-0b78-4d05-86b7-8bd7481ed56d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_62a03e05-f60d-4604-bf7a-0f5d831ccf64" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_078823e7-0b78-4d05-86b7-8bd7481ed56d" xlink:to="loc_us-gaap_PreferredStockValue_62a03e05-f60d-4604-bf7a-0f5d831ccf64" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_ecca426d-28a2-415f-98ac-a33ea4048dc1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_078823e7-0b78-4d05-86b7-8bd7481ed56d" xlink:to="loc_us-gaap_CommonStockValue_ecca426d-28a2-415f-98ac-a33ea4048dc1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalCommonStock_d08f4280-31da-4d4d-8ca1-dacf8cee3ce3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalCommonStock"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_078823e7-0b78-4d05-86b7-8bd7481ed56d" xlink:to="loc_us-gaap_AdditionalPaidInCapitalCommonStock_d08f4280-31da-4d4d-8ca1-dacf8cee3ce3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_2d0ea718-7502-4a06-a937-1eac5d25941b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_078823e7-0b78-4d05-86b7-8bd7481ed56d" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_2d0ea718-7502-4a06-a937-1eac5d25941b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_59fa4d02-4008-4ca9-9114-0bdab0c61eaa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_078823e7-0b78-4d05-86b7-8bd7481ed56d" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_59fa4d02-4008-4ca9-9114-0bdab0c61eaa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_9b3bdcea-ccef-41cc-835d-4a6bde4a5331" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_d216e7aa-f916-422b-9dda-d987d6008cca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_9b3bdcea-ccef-41cc-835d-4a6bde4a5331" xlink:to="loc_us-gaap_AccountsPayableCurrent_d216e7aa-f916-422b-9dda-d987d6008cca" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nrix_AccruedExpensesAndOtherLiabilitiesCurrent_906d1a3c-5b5d-4ebb-9efc-3bc42b1f6a52" xlink:href="nrix-20230531.xsd#nrix_AccruedExpensesAndOtherLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_9b3bdcea-ccef-41cc-835d-4a6bde4a5331" xlink:to="loc_nrix_AccruedExpensesAndOtherLiabilitiesCurrent_906d1a3c-5b5d-4ebb-9efc-3bc42b1f6a52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_408ed981-474d-4ed3-8a39-bf7d1ea61a5c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_9b3bdcea-ccef-41cc-835d-4a6bde4a5331" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_408ed981-474d-4ed3-8a39-bf7d1ea61a5c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContractWithCustomerLiabilityCurrent_d1751baa-316c-43dd-b315-246fef519ca9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContractWithCustomerLiabilityCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_9b3bdcea-ccef-41cc-835d-4a6bde4a5331" xlink:to="loc_us-gaap_ContractWithCustomerLiabilityCurrent_d1751baa-316c-43dd-b315-246fef519ca9" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.nurixtx.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="simple" xlink:href="nrix-20230531.xsd#CondensedConsolidatedStatementsofOperations"/>
  <link:calculationLink xlink:role="http://www.nurixtx.com/role/CondensedConsolidatedStatementsofOperations" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_b613e817-2472-45c2-85bf-3e117b8e3e2a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_630cfe89-d1b8-4fb2-921c-8b7ab69a8617" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_b613e817-2472-45c2-85bf-3e117b8e3e2a" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_630cfe89-d1b8-4fb2-921c-8b7ab69a8617" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_e05459b0-96b0-4b22-961b-70db1a2afcdc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_b613e817-2472-45c2-85bf-3e117b8e3e2a" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_e05459b0-96b0-4b22-961b-70db1a2afcdc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_389c62af-c49c-4b67-9b70-9ba1812241d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_cf2ae387-c3ea-48e0-94b0-197db4549364" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_389c62af-c49c-4b67-9b70-9ba1812241d0" xlink:to="loc_us-gaap_Revenues_cf2ae387-c3ea-48e0-94b0-197db4549364" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_0d4a9b30-b84d-4324-9d82-b5dfbbdf4345" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_389c62af-c49c-4b67-9b70-9ba1812241d0" xlink:to="loc_us-gaap_OperatingExpenses_0d4a9b30-b84d-4324-9d82-b5dfbbdf4345" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_f8a96738-4790-4c64-a523-fcc4a9ac251e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_f960dd41-db7e-45ec-9014-b34204dd372d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_f8a96738-4790-4c64-a523-fcc4a9ac251e" xlink:to="loc_us-gaap_OperatingIncomeLoss_f960dd41-db7e-45ec-9014-b34204dd372d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestAndOtherIncome_0012774c-04b7-46f2-95e3-890cf10dc7a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestAndOtherIncome"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_f8a96738-4790-4c64-a523-fcc4a9ac251e" xlink:to="loc_us-gaap_InterestAndOtherIncome_0012774c-04b7-46f2-95e3-890cf10dc7a5" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.nurixtx.com/role/CondensedConsolidatedStatementsofComprehensiveLoss" xlink:type="simple" xlink:href="nrix-20230531.xsd#CondensedConsolidatedStatementsofComprehensiveLoss"/>
  <link:calculationLink xlink:role="http://www.nurixtx.com/role/CondensedConsolidatedStatementsofComprehensiveLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_ec760646-cf6c-4cc4-bfe1-fc2aac55bc3b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_b1da0b6c-a419-46ca-ad2f-0fa5facd34cd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_ec760646-cf6c-4cc4-bfe1-fc2aac55bc3b" xlink:to="loc_us-gaap_NetIncomeLoss_b1da0b6c-a419-46ca-ad2f-0fa5facd34cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_efd33271-1036-4e4b-a89e-6784b332c73f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_ec760646-cf6c-4cc4-bfe1-fc2aac55bc3b" xlink:to="loc_us-gaap_OtherComprehensiveIncomeUnrealizedHoldingGainLossOnSecuritiesArisingDuringPeriodNetOfTax_efd33271-1036-4e4b-a89e-6784b332c73f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.nurixtx.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="nrix-20230531.xsd#CondensedConsolidatedStatementsofCashFlows"/>
  <link:calculationLink xlink:role="http://www.nurixtx.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_8e9c9957-5413-4151-8d98-ef3ccc533785" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashNoncurrent_90683326-0ae6-4565-a611-dc95de888953" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_8e9c9957-5413-4151-8d98-ef3ccc533785" xlink:to="loc_us-gaap_RestrictedCashNoncurrent_90683326-0ae6-4565-a611-dc95de888953" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_956730bf-c6d6-4b2c-8f13-d4c6d620ebe6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsIncludingDisposalGroupAndDiscontinuedOperations_8e9c9957-5413-4151-8d98-ef3ccc533785" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_956730bf-c6d6-4b2c-8f13-d4c6d620ebe6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3a9cecfe-f3fc-4e9c-b262-4eca5c99aed3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_09f80d3c-992f-43a8-96af-f0885c3246f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3a9cecfe-f3fc-4e9c-b262-4eca5c99aed3" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_09f80d3c-992f-43a8-96af-f0885c3246f0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a2595874-97b8-4dde-9859-9355ae0739b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3a9cecfe-f3fc-4e9c-b262-4eca5c99aed3" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a2595874-97b8-4dde-9859-9355ae0739b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0b5a2307-b225-445d-add0-47408bc551fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_3a9cecfe-f3fc-4e9c-b262-4eca5c99aed3" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0b5a2307-b225-445d-add0-47408bc551fc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_83e520dc-70ad-4902-ae24-d87a4a45f3a4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_e0a85d1a-a949-430b-98bb-0e40504f600f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_83e520dc-70ad-4902-ae24-d87a4a45f3a4" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_e0a85d1a-a949-430b-98bb-0e40504f600f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_c3fdb1d2-c0ed-436e-8c83-41871a3ff2b7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_83e520dc-70ad-4902-ae24-d87a4a45f3a4" xlink:to="loc_us-gaap_ShareBasedCompensation_c3fdb1d2-c0ed-436e-8c83-41871a3ff2b7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_90169bc5-4833-46da-a724-a652ed439995" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_83e520dc-70ad-4902-ae24-d87a4a45f3a4" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_90169bc5-4833-46da-a724-a652ed439995" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_2db70452-2476-4396-a376-6ef2fbe5a355" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_83e520dc-70ad-4902-ae24-d87a4a45f3a4" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_2db70452-2476-4396-a376-6ef2fbe5a355" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnDispositionOfAssets_dbe2cae5-6728-4754-a0a8-eaebcb7440c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainLossOnDispositionOfAssets"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_83e520dc-70ad-4902-ae24-d87a4a45f3a4" xlink:to="loc_us-gaap_GainLossOnDispositionOfAssets_dbe2cae5-6728-4754-a0a8-eaebcb7440c0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_6108f3b9-f77e-4244-a673-fe8ece11a7ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_83e520dc-70ad-4902-ae24-d87a4a45f3a4" xlink:to="loc_us-gaap_AccretionAmortizationOfDiscountsAndPremiumsInvestments_6108f3b9-f77e-4244-a673-fe8ece11a7ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_a1eaac34-1492-453a-b81d-0a829072ce89" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_83e520dc-70ad-4902-ae24-d87a4a45f3a4" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_a1eaac34-1492-453a-b81d-0a829072ce89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_10e77500-c0bf-4584-b674-30b95a591442" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_83e520dc-70ad-4902-ae24-d87a4a45f3a4" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_10e77500-c0bf-4584-b674-30b95a591442" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_1b0af367-be5a-4c42-9945-237923d06a9f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInContractWithCustomerLiability"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_83e520dc-70ad-4902-ae24-d87a4a45f3a4" xlink:to="loc_us-gaap_IncreaseDecreaseInContractWithCustomerLiability_1b0af367-be5a-4c42-9945-237923d06a9f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_0a746f3a-e785-4916-b14f-e97b3e2a73ae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_83e520dc-70ad-4902-ae24-d87a4a45f3a4" xlink:to="loc_us-gaap_NetIncomeLoss_0a746f3a-e785-4916-b14f-e97b3e2a73ae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationAndAmortization_539ae7b5-5697-476c-8fe4-edaa60ec50fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DepreciationAndAmortization"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_83e520dc-70ad-4902-ae24-d87a4a45f3a4" xlink:to="loc_us-gaap_DepreciationAndAmortization_539ae7b5-5697-476c-8fe4-edaa60ec50fb" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_d320389d-c800-4b3f-b8aa-6782291305ad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_83e520dc-70ad-4902-ae24-d87a4a45f3a4" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_d320389d-c800-4b3f-b8aa-6782291305ad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities_5f590f3d-0639-4c7a-9ca6-ca545c55c460" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_83e520dc-70ad-4902-ae24-d87a4a45f3a4" xlink:to="loc_us-gaap_IncreaseDecreaseInOtherAccountsPayableAndAccruedLiabilities_5f590f3d-0639-4c7a-9ca6-ca545c55c460" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_75528132-742b-46f3-b5e3-b4b3e9e0d79b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireMarketableSecurities_a46dee51-0fcf-45f8-9c5b-ce9d3bb49851" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireMarketableSecurities"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_75528132-742b-46f3-b5e3-b4b3e9e0d79b" xlink:to="loc_us-gaap_PaymentsToAcquireMarketableSecurities_a46dee51-0fcf-45f8-9c5b-ce9d3bb49851" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_07ea928e-a589-42fb-8b35-a7519e24a837" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_75528132-742b-46f3-b5e3-b4b3e9e0d79b" xlink:to="loc_us-gaap_ProceedsFromSaleMaturityAndCollectionsOfInvestments_07ea928e-a589-42fb-8b35-a7519e24a837" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_07c1257a-6bc9-4fd9-8bf0-a0ba4dbd3547" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_75528132-742b-46f3-b5e3-b4b3e9e0d79b" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_07c1257a-6bc9-4fd9-8bf0-a0ba4dbd3547" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_3409524b-f40e-4aa2-bfd1-537b5a92ec09" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_nrix_ProceedsFromStockOptionsAndWarrantsExercised_0326154a-d668-46d2-a0ef-b118023a4032" xlink:href="nrix-20230531.xsd#nrix_ProceedsFromStockOptionsAndWarrantsExercised"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_3409524b-f40e-4aa2-bfd1-537b5a92ec09" xlink:to="loc_nrix_ProceedsFromStockOptionsAndWarrantsExercised_0326154a-d668-46d2-a0ef-b118023a4032" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans_500b154b-4c39-4801-a970-d33ba0c782c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_3409524b-f40e-4aa2-bfd1-537b5a92ec09" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSharesUnderIncentiveAndShareBasedCompensationPlans_500b154b-4c39-4801-a970-d33ba0c782c0" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.nurixtx.com/role/CondensedConsolidatedBalanceSheetComponentsSummaryofPropertyandEquipmentDetails" xlink:type="simple" xlink:href="nrix-20230531.xsd#CondensedConsolidatedBalanceSheetComponentsSummaryofPropertyandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.nurixtx.com/role/CondensedConsolidatedBalanceSheetComponentsSummaryofPropertyandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_80623b51-78ec-4680-b3b3-c5542c9afe15" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_d41660ef-9cd9-4989-91e8-bc0b94aecefa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_80623b51-78ec-4680-b3b3-c5542c9afe15" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_d41660ef-9cd9-4989-91e8-bc0b94aecefa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_22322938-e1b3-4a9f-80cf-46016eed9b45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_80623b51-78ec-4680-b3b3-c5542c9afe15" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_22322938-e1b3-4a9f-80cf-46016eed9b45" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.nurixtx.com/role/CondensedConsolidatedBalanceSheetComponentsScheduleofAccruedExpensesandOtherCurrentLiabilitiesDetails" xlink:type="simple" xlink:href="nrix-20230531.xsd#CondensedConsolidatedBalanceSheetComponentsScheduleofAccruedExpensesandOtherCurrentLiabilitiesDetails"/>
  <link:calculationLink xlink:role="http://www.nurixtx.com/role/CondensedConsolidatedBalanceSheetComponentsScheduleofAccruedExpensesandOtherCurrentLiabilitiesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_nrix_AccruedExpensesAndOtherLiabilitiesCurrent_6fdaa2a2-c145-4c8a-b68a-b0804857510b" xlink:href="nrix-20230531.xsd#nrix_AccruedExpensesAndOtherLiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_d3017b56-fa81-4de8-8553-9d1584ebd602" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_nrix_AccruedExpensesAndOtherLiabilitiesCurrent_6fdaa2a2-c145-4c8a-b68a-b0804857510b" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_d3017b56-fa81-4de8-8553-9d1584ebd602" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_nrix_AccruedContractResearchAndLabSupplies_8b0b603e-7283-411b-ba75-6ac1b733b658" xlink:href="nrix-20230531.xsd#nrix_AccruedContractResearchAndLabSupplies"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_nrix_AccruedExpensesAndOtherLiabilitiesCurrent_6fdaa2a2-c145-4c8a-b68a-b0804857510b" xlink:to="loc_nrix_AccruedContractResearchAndLabSupplies_8b0b603e-7283-411b-ba75-6ac1b733b658" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_4ec3adfe-9829-4bc5-9029-27639bd3f078" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_nrix_AccruedExpensesAndOtherLiabilitiesCurrent_6fdaa2a2-c145-4c8a-b68a-b0804857510b" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_4ec3adfe-9829-4bc5-9029-27639bd3f078" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TaxesPayableCurrent_4d95ea9d-9d66-4682-ae48-cfa5fd2179cd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TaxesPayableCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_nrix_AccruedExpensesAndOtherLiabilitiesCurrent_6fdaa2a2-c145-4c8a-b68a-b0804857510b" xlink:to="loc_us-gaap_TaxesPayableCurrent_4d95ea9d-9d66-4682-ae48-cfa5fd2179cd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesCurrent_f779a26d-2c1b-46e5-b92b-fcb49b7ce355" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherLiabilitiesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_nrix_AccruedExpensesAndOtherLiabilitiesCurrent_6fdaa2a2-c145-4c8a-b68a-b0804857510b" xlink:to="loc_us-gaap_OtherLiabilitiesCurrent_f779a26d-2c1b-46e5-b92b-fcb49b7ce355" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.nurixtx.com/role/FairValueMeasurementsSummaryofInvestmentsFairValueMeasurementonRecurringBasisDetails" xlink:type="simple" xlink:href="nrix-20230531.xsd#FairValueMeasurementsSummaryofInvestmentsFairValueMeasurementonRecurringBasisDetails"/>
  <link:calculationLink xlink:role="http://www.nurixtx.com/role/FairValueMeasurementsSummaryofInvestmentsFairValueMeasurementonRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_7b5a5c55-ee05-40ac-99a1-a219ec0324cd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3de13ac2-a8db-441e-b97a-a7a7b9d2cb02" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_7b5a5c55-ee05-40ac-99a1-a219ec0324cd" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedGainBeforeTax_3de13ac2-a8db-441e-b97a-a7a7b9d2cb02" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_78a12f44-eb7d-4482-be31-5feb23447e22" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_7b5a5c55-ee05-40ac-99a1-a219ec0324cd" xlink:to="loc_us-gaap_AvailableForSaleDebtSecuritiesAccumulatedGrossUnrealizedLossBeforeTax_78a12f44-eb7d-4482-be31-5feb23447e22" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_ce81b120-46d8-4de1-9c49-cec925587cc5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AvailableForSaleSecuritiesDebtSecurities"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AvailableForSaleDebtSecuritiesAmortizedCostBasis_7b5a5c55-ee05-40ac-99a1-a219ec0324cd" xlink:to="loc_us-gaap_AvailableForSaleSecuritiesDebtSecurities_ce81b120-46d8-4de1-9c49-cec925587cc5" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
