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<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2021-02-15T23:53:10.4952941+00:00 -->
<!-- Version            : 5.0.1.571 -->
<!-- Package ID         : 8d311c36ac804372bccb02da639382d2 -->
<!-- Copyright (c) 2021 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="nrix_DevelopmentMilestonePaymentsReceivable" name="DevelopmentMilestonePaymentsReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_SalesMilestonePaymentsReceivable" name="SalesMilestonePaymentsReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_AdditionalFeesReceivableRelatedToTargetLicensingReservationAndSelectionAndResearchTermExtensions" name="AdditionalFeesReceivableRelatedToTargetLicensingReservationAndSelectionAndResearchTermExtensions" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_ResearchMilestonePayment" name="ResearchMilestonePayment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_PaymentInAdditionalFeesRelatedToCertainTargetReservation" name="PaymentInAdditionalFeesRelatedToCertainTargetReservation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_NumberOfResearchMilestonesRecognized" name="NumberOfResearchMilestonesRecognized" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="nrix_CollaborationAgreementContractTerm" name="CollaborationAgreementContractTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="nrix_VariableConsiderationIncludedInTransactionPrice" name="VariableConsiderationIncludedInTransactionPrice" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_AdditionalPaymentReceivedToExerciseOptionToExpandNumberOfTargets" name="AdditionalPaymentReceivedToExerciseOptionToExpandNumberOfTargets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_MilestonePaymentsAdditionalFeesReceivable" name="MilestonePaymentsAdditionalFeesReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_RegulatoryMilestonePaymentsReceivable" name="RegulatoryMilestonePaymentsReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_AdditionalFeesReceivableRelatedToTargetLicensingAndReservation" name="AdditionalFeesReceivableRelatedToTargetLicensingAndReservation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_CollaborativeAgreementExpectedTransactionPrice" name="CollaborativeAgreementExpectedTransactionPrice" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_CollaborativeAgreementAdditionalTransactionPrice" name="CollaborativeAgreementAdditionalTransactionPrice" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_ContractualInitialResearchPeriod" name="ContractualInitialResearchPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="nrix_LaboratoryEquipmentMember" name="LaboratoryEquipmentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_SoftwareMember" name="SoftwareMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_SoftwareInProgressMember" name="SoftwareInProgressMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_AccruedContractResearchAndLabSupplies" name="AccruedContractResearchAndLabSupplies" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="nrix_AvailableForSalesSecuritiesNoncurrentMember" name="AvailableForSalesSecuritiesNoncurrentMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_LongTermInvestmentsMember" name="LongTermInvestmentsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_TransfersOfFinancialInstrumentsBetweenValuationLevels" name="TransfersOfFinancialInstrumentsBetweenValuationLevels" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="nrix_CommonStockAbstract" name="CommonStockAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_SeriesAOneRedeemableConvertiblePreferredStockMember" name="SeriesAOneRedeemableConvertiblePreferredStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_SeriesATwoRedeemableConvertiblePreferredStockMember" name="SeriesATwoRedeemableConvertiblePreferredStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_SeriesBRedeemableConvertiblePreferredStockMember" name="SeriesBRedeemableConvertiblePreferredStockMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_ShareBasedCompensationArrangementByShareBasedPaymentAwardCombinedVotingPowerOfCommonStockHoldingPercentage" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardCombinedVotingPowerOfCommonStockHoldingPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="nrix_TwoThousandTwentyEquityIncentivePlanMember" name="TwoThousandTwentyEquityIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_IncentiveStockOptionMember" name="IncentiveStockOptionMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_NonStatutoryStockOptionAndOptionsGrantedToConsultantsMember" name="NonStatutoryStockOptionAndOptionsGrantedToConsultantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_TwoThousandTwelveEquityIncentivePlanMember" name="TwoThousandTwelveEquityIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_TwoThousandTwentyEmployeeStockPurchasePlanMember" name="TwoThousandTwentyEmployeeStockPurchasePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_TwoThousandTwentyPlanAndTwoThousandTwelvePlanMember" name="TwoThousandTwentyPlanAndTwoThousandTwelvePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsSharesSubjectToRepurchase" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsSharesSubjectToRepurchase" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="nrix_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExerciseValueOfSharesSubjectToRepurchase" name="ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExerciseValueOfSharesSubjectToRepurchase" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_StockOptionsAndEmployeeStockPurchasePlanMember" name="StockOptionsAndEmployeeStockPurchasePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_CARESActMember" name="CARESActMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_EffectiveIncomeTaxRateReconciliationUnrecognizedIncomeTaxBenefits" name="EffectiveIncomeTaxRateReconciliationUnrecognizedIncomeTaxBenefits" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="nrix_EffectiveIncomeTaxRateReconciliationFederalRateImpactDueToCARESAct" name="EffectiveIncomeTaxRateReconciliationFederalRateImpactDueToCARESAct" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="nrix_NetOperatingLossExpirationYear" name="NetOperatingLossExpirationYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="nrix_OperatingLossCarryforwardsNotSubjectToExpiration" name="OperatingLossCarryforwardsNotSubjectToExpiration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_NetOperatingLossesCarryforwardPeriod" name="NetOperatingLossesCarryforwardPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="nrix_TaxCreditCarryforwardExpirationYear" name="TaxCreditCarryforwardExpirationYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="nrix_TaxCreditCarryforwardExpirationPeriod" name="TaxCreditCarryforwardExpirationPeriod" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="nrix_NetOperatingLossUnutilizedAmount" name="NetOperatingLossUnutilizedAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_IncomeTaxExaminationPeriodOpenForExamination" name="IncomeTaxExaminationPeriodOpenForExamination" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="nrix_IncomeTaxDecreaseInTaxCreditsResearchAmount" name="IncomeTaxDecreaseInTaxCreditsResearchAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_NetOperatingLossCarrybackRefundClaimAdditionalAmountOfIncomeTaxCARESAct" name="NetOperatingLossCarrybackRefundClaimAdditionalAmountOfIncomeTaxCARESAct" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_PercentageOfNetOperatingLossCarryoverAndCarrybackOffsetOfTaxableIncomeCARESAct" name="PercentageOfNetOperatingLossCarryoverAndCarrybackOffsetOfTaxableIncomeCARESAct" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="nrix_NetOperatingLossCarrybackPeriodCARESAct" name="NetOperatingLossCarrybackPeriodCARESAct" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="nrix_NetOperatingLossCarrybackRefundClaimCARESAct" name="NetOperatingLossCarrybackRefundClaimCARESAct" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_IncomeTaxesRefundReceivedOnFirstRefundClaimCARESAct" name="IncomeTaxesRefundReceivedOnFirstRefundClaimCARESAct" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="nrix_IncomeInterestReceivedCARESAct" name="IncomeInterestReceivedCARESAct" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="nrix_OptionEarlyExercisedSubjectToVestingMember" name="OptionEarlyExercisedSubjectToVestingMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_QuarterlyFinancialInformationLineItems" name="QuarterlyFinancialInformationLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="nrix_QuarterlyFinancialInformationTable" name="QuarterlyFinancialInformationTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
</xsd:schema>
