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Prepaid expenses and other current assets Prepaid Expense and Other Assets, Current Entity Address, Postal Zip Code Entity Address, Postal Zip Code Restatement Determination Date Restatement Determination Date Share-Based Payment Arrangement [Abstract] Share-Based Payment Arrangement [Abstract] Cash, cash equivalents and restricted cash at beginning of period Cash, cash equivalents and restricted cash at end of period Total cash, cash equivalents and restricted cash Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation Income Statement [Abstract] Income Statement [Abstract] Provision for income taxes Income Tax Expense (Benefit) Greater than 12 months Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer Clinical milestone payment Proceeds From Collaboration Agreement, Clinical Milestone Payment Proceeds From Collaboration Agreement, Clinical Milestone Payment Purchases of marketable securities Payments to Acquire Marketable Securities Sale of Stock Sale of Stock [Domain] Accrued taxes Taxes Payable, Current Preferred stock, shares issued (in shares) Preferred Stock, Shares Issued Pension Adjustments Service Cost Pension Adjustments Service Cost [Member] Product and Service [Domain] Product and Service [Domain] Fair Value Debt Securities, Available-for-Sale [Abstract] Fair Value Hierarchy and NAV Fair Value Hierarchy and NAV [Axis] Total property and equipment, gross Property, Plant and Equipment, Gross Cash and short-term investments Cash, Cash Equivalents, and Short-Term Investments Restatement does not require Recovery Restatement Does Not Require Recovery [Text Block] Organization, Consolidation and Presentation of Financial Statements [Abstract] Organization, Consolidation and Presentation of Financial Statements [Abstract] Amortization of operating lease right-of-use assets Operating Lease, Right-of-Use Asset, Periodic Reduction Compensation Actually Paid vs. Company Selected Measure Compensation Actually Paid vs. Company Selected Measure [Text Block] Proceeds from exercise of stock options Proceeds from Stock Options Exercised City Area Code City Area Code Award Timing, How MNPI Considered Award Timing, How MNPI Considered [Text Block] All Trading Arrangements All Trading Arrangements [Member] Equity Awards Adjustments, Footnote Equity Awards Adjustments, Footnote [Text Block] Total Shareholder Return Vs Peer Group Total Shareholder Return Vs Peer Group [Text Block] Schedule of Accrued Expenses and Other Current Liabilities Schedule Of Accrued Expenses And Other Current Liabilities Table [Table Text Block] Schedule of accrued expenses and other current liabilities. 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Weighted-average grant date fair value, RSUs forfeited (in USD per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value Stockholdersʼ equity: Equity, Attributable to Parent [Abstract] Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year [Member] Entity Address, Address Line One Entity Address, Address Line One Entity Address, Address Line Two Entity Address, Address Line Two Research and development Total research and development expenses Research and Development Expense Accumulated other comprehensive income (loss) AOCI Attributable to Parent [Member] Operating lease liabilities, net of current portion Operating Lease, Liability, Noncurrent Balance Sheet Related Disclosures [Abstract] Balance Sheet Related Disclosures [Abstract] Reportable Segment Reportable Segment [Member] Reportable Segment Fair Value as of Grant Date Award Grant Date Fair Value Entity Registrant Name Entity Registrant Name Stock Price or TSR Estimation Method Stock Price or TSR Estimation Method [Text Block] Equity Incentive Plans Equity Incentive Plans [Member] Equity Incentive Plans Collaboration revenue Collaboration Revenue [Member] Collaboration Revenue RSUs granted (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period RSUs forfeited (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period Related Party Transaction [Line Items] Related Party Transaction [Line Items] Document Quarterly Report Document Quarterly Report Less than 12 months Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months Issuance costs, common stock Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs Changed Peer Group, Footnote Changed Peer Group, Footnote [Text Block] Accrued interest receivable Interest Receivable, Current Counterparty Name Counterparty Name [Domain] Number of operating segments Number of Operating Segments Net accretion of discount on marketable securities Accretion (Amortization) of Discounts and Premiums, Investments Gwenn M. Hansen [Member] Gwenn M. 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Defined Contribution Plan Defined Contribution Plan [Text Block] Other Risks and Uncertainties Other Risks And Uncertainties [Policy Text Block] Other risks and uncertainties policy. Document Type Document Type Gross Unrealized Loss Debt Securities, Available-for-Sale, Unrealized Loss Position [Abstract] Net Loss Per Share Earnings Per Share [Text Block] Name Outstanding Recovery, Individual Name Product and Service [Axis] Product and Service [Axis] Unrealized loss, short-term Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax, Current Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax, Current Proceeds from issuances of common stock in “at the market” financing, net of issuance costs Proceeds from issuance of common stock Proceeds from Issuance of Common Stock Zelebrudomide (NX-2127) Zelebrudomide (NX-2127) [Member] Zelebrudomide (NX-2127) Total revenue Revenue Revenue from Contract with Customer, Excluding Assessed Tax Transfers Fair Value, Measurement with Unobservable Inputs Reconciliation, Recurring Basis, Asset, Transfers, Net All Individuals All Individuals [Member] Fair Value Disclosures [Abstract] Fair Value Disclosures [Abstract] Purchases of property and equipment Payments to Acquire Property, Plant, and Equipment Name Forgone Recovery, Individual Name Total current assets Assets, Current Statistical Measurement Statistical Measurement [Axis] Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested [Member] Gilead Agreement Gilead Agreement [Member] Gilead agreement. Registered Direct Offerings Registered Direct Offerings [Member] Registered direct offerings. 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Deferred revenue Increase (Decrease) in Contract with Customer, Liability 2024 Public Offering Public Offering 2024 [Member] Public Offering 2024 Chief Financial Officer Chief Financial Officer [Member] Organization Consolidation And Presentation Of Financial Statements [Table] Organization Consolidation And Presentation Of Financial Statements [Table] Organization, consolidation and presentation of financial statements. Accrued contract research and lab supplies Accrued Contract Research And Lab Supplies Accrued contract research and lab supplies. Contractual initial research period Contractual Initial Research Period Contractual initial research period. Upfront payment Upfront Payment Upfront payment. Weighted-average exercise price, options exercised (in USD per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table] Collaborative Arrangement and Arrangement Other than Collaborative [Table] Award Timing Disclosures [Line Items] Weighted-average exercise price, options granted (in USD per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price Accrued compensation Employee-related Liabilities, Current Future minimum lease payments Lessee, Operating Lease, Liability, to be Paid Renewal term Lessee, Operating Lease, Renewal Term Hans van Houte [Member] Hans van Houte Common Stock Equity [Text Block] Net loss Net loss Net Income (Loss) Attributable to Parent Schedule of Debt Securities, Available-for-Sale, Unrealized Loss Position, Fair Value Debt Securities, Available-for-Sale, Unrealized Loss Position, Fair Value [Table Text Block] Expiration Date Trading Arrangement Expiration Date Bexobrutideg (NX-5948) Bexobrutideg (NX-5948) [Member] Bexobrutideg (NX-5948) Expenses related to the healthcare plan premiums Related Party Transaction, Amounts of Transaction Property and equipment, net Total property and equipment, net Property, Plant and Equipment, Net Collaboration agreement contract term Collaboration Agreement Contract Term Collaboration agreement contract term. Preferred stock, shares authorized (in shares) Preferred Stock, Shares Authorized Numerator: Net Income (Loss) Attributable to Parent [Abstract] Adoption Date Trading Arrangement Adoption Date Issuance of Series D redeemable convertible preferred stock, per share (in USD per share) Shares Issued, Price Per Share Compensation Actually Paid vs. Net Income Compensation Actually Paid vs. Net Income [Text Block] Contract assets Contract with Customer, Asset, after Allowance for Credit Loss Proceeds from issuance of common stock under employee stock purchase plan Proceeds, Issuance of Shares, Share-Based Payment Arrangement, Excluding Option Exercised Entity Current Reporting Status Entity Current Reporting Status Awards Close in Time to MNPI Disclosures Awards Close in Time to MNPI Disclosures [Table] Loss from operations Operating Income (Loss) Accumulated deficit Retained Earnings (Accumulated Deficit) Vesting of restricted stock units (in shares) Restricted Stock, Shares Issued Net of Shares for Tax Withholdings Transaction Transaction [Domain] Financial Instrument Financial Instrument [Axis] Statement of Financial Position [Abstract] Statement of Financial Position [Abstract] Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested [Member] Executive Category: Executive Category [Axis] Pfizer Pfizer [Member] Pfizer Greater than 12 months Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer, Accumulated Loss Current Fiscal Year End Date Current Fiscal Year End Date Less than 12 months Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months, Accumulated Loss Subsequent Event Type [Domain] Subsequent Event Type [Domain] Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table [Member] Weighted-average grant date fair value Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value [Abstract] Shares available for grant under the stock plans (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant Statement [Table] Statement [Table] Adjustments to reconcile net loss to net cash used in operating activities: Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract] Collaboration Agreements Collaborative Arrangement Disclosure [Text Block] Cash flows from financing activities Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract] Equity Awards Adjustments, Excluding Value Reported in Compensation Table Equity Awards Adjustments, Excluding Value Reported in the Compensation Table [Member] Total Debt Securities, Available-for-Sale, Unrealized Loss Position, Accumulated Loss Additional payment received to exercise option to expand number of targets Additional Payment Received To Exercise Option To Expand Number Of Targets Additional payment received to exercise option to expand number of targets. Recorded deferred revenue Contract with Customer, Liability Anti-dilutive securities excluded from computation of diluted net loss per share (in shares) Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount Denominator: Weighted Average Number of Shares Outstanding, Diluted [Abstract] All Adjustments to Compensation All Adjustments to Compensation [Member] Amendment Flag Amendment Flag Sale price of stock (in USD per share) Sale of Stock, Price Per Share Other Commitments [Table] Other Commitments [Table] Termination Date Trading Arrangement Termination Date Net cash provided by financing activities Cash Provided by (Used in) Financing Activity, Including Discontinued Operation Insider Trading Policies and Procedures Adopted Insider Trading Policies and Procedures Adopted [Flag] Measure: Measure [Axis] Schedule of Activity under 2020 Plan and 2012 Plan Share-Based Payment Arrangement, Option, Activity [Table Text Block] Research and development milestone payments Revenue, Remaining Performance Obligation, Variable Consideration Amount, Research And Development Milestones Revenue, Remaining Performance Obligation, Variable Consideration Amount, Research And Development Milestones Long-Lived Tangible Asset Long-Lived Tangible Asset [Domain] Schedule of Investments Fair Value Measurement on Recurring Basis Fair Value, Assets Measured on Recurring Basis [Table Text Block] Weighted-average number of shares outstanding, basic (in shares) Weighted Average Number of Shares Outstanding, Basic Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table] Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table] Schedule of Computation of Basic and Diluted Net Loss per Share Attributable to Common Stockholders Schedule of Earnings Per Share, Basic and Diluted [Table Text Block] Related Party Transaction [Domain] Related Party Transaction [Domain] Segment Reporting [Abstract] Pay vs Performance Disclosure, Table Pay vs Performance [Table Text Block] Operating lease expenses, excluding variable lease payments Operating Lease, Expense Forgone Recovery due to Violation of Home Country Law, Amount Forgone Recovery due to Violation of Home Country Law, Amount Entity Tax Identification Number Entity Tax Identification Number Weighted-average price per share (in USD per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Per Share Weighted Average Price of Shares Purchased Weighted-average exercise price, beginning balance (in USD per share) Weighted-average exercise price, ending balance (in USD per share) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price Forgone Recovery due to Expense of Enforcement, Amount Forgone Recovery due to Expense of Enforcement, Amount Share Based Compensation Arrangement By Share Based Payment Award [Line Items] Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items] Common stock, par value (in USD per share) Common Stock, Par or Stated Value Per Share Common stock, shares issued (in shares) Common Stock, Shares, Issued Warrants offering expenses Warrants Offering Expenses Warrants offering expenses. Number of performance obligations Number Of Performance Obligations Number Of Performance Obligations Options granted (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross Use of Estimates Use of Estimates, Policy [Policy Text Block] Trading Arrangement: Trading Arrangement [Axis] Total Shareholder Return Amount Total Shareholder Return Amount Insider Trading Arrangements [Line Items] Proceeds from issuance of warrants Proceeds from Issuance of Warrants Security Exchange Name Security Exchange Name Weighted-average exercise price, options forfeited (in USD per share) Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price Number of RSUs Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Outstanding [Roll Forward] Tenant improvements Tenant Improvements Allowance for credit losses Debt Securities, Available-for-Sale, Allowance for Credit Loss, Excluding Accrued Interest Maximum increase or decrease percentage of warrants Maximum Increase Or Decrease Percentage Of Warrants Maximum increase or decrease percentage of warrants. Total liabilities Liabilities Antidilutive Securities, Name Antidilutive Securities, Name [Domain] Purchase price of warrants (in USD per share) Class Of Warrant Or Right, Purchase Price Of Warrants Or Rights Class Of Warrant Or Right, Purchase Price Of Warrants Or Rights Additions to property and equipment included in accounts payable and accrued expenses and other current liabilities Capital Expenditures Incurred but Not yet Paid At the Market Offering At The Market Offerings [Member] At the market offerings. Marketable securities Estimated fair value, short-term Debt Securities, Available-for-Sale, Excluding Accrued Interest, Current Pension Adjustments Prior Service Cost Pension Adjustments Prior Service Cost [Member] Operating expenses: Operating Expenses [Abstract] Material Terms of Trading Arrangement Material Terms of Trading Arrangement [Text Block] Other Other Liabilities, Current Revenue recognized Contract With Customer Liability Revenue Recognized Excluding Opening Balance Contract With Customer Liability Revenue Recognized Excluding Opening Balance Issuance of common stock in “at the market” financing, net of issuance costs Stock Issued During Period, Value, New Issues Statement [Line Items] Statement [Line Items] Rule 10b5-1 Arrangement Adopted Rule 10b5-1 Arrangement Adopted [Flag] Cash and cash equivalents Cash and cash equivalents Cash and Cash Equivalent Counterparty Name Counterparty Name [Axis] Schedule of RSU Activity Share-Based Payment Arrangement, Restricted Stock Unit, Activity [Table Text Block] Common stock Common Stock [Member] RSUs vested (in shares) Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period Entity Incorporation, State or Country Code Entity Incorporation, State or Country Code Non-NEOs Non-NEOs [Member] Net decrease in cash, cash equivalents and restricted cash Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation Healthcare Plan Provider Trust for Benefit of Employees [Member] Accrued professional services Accrued Professional Fees, Current